Pharmacology of antacids

Antipeptic activity of antacids.

An in vitro experiment based on the digestion of haemoglobin with pepsin was carried out to test the claim made by some manufacturers that the antacids used in their proprietary preparations had an intrinsic antipeptic activity independent of the change brought about by alteration of pH. In no case could these claims be substantiated.

Comparative study of commercial antacids

Comparative study of four antacids.

Four antacid preparations have been studied in a stratified, randomized, double-blind trial to evaluate criteria which determine patients' acceptance of this type of therapy. There was a considerable range of judgements about palatability, but preference was determined not only by factors such as the smell, taste, texture and after-taste of the preparation, but also by the order in which the an...

Gastric emptying of two radiolabelled antacids.

The rate of gastric emptying of two antacids, magaldrate and Maalox, was investigated using scintigraphy. Successful labelling of the antacids was carried out with 99mTc. The stability of the 99mTc-labelled antacids was satisfactory and there was no difference in antacid capacity between the labelled and unlabelled antacids. The studies were carried out on 15 healthy male volunteers. After an e...

In Vitro Evaluation of Some Ayurvedic Antacids

The ayurvedic proprietary antacid preparations available in the Indian market were analysed for their antacid activity and compared with allopathic antacid preparations. This study urges the need for standardization of antacid products with in vitro  parameters.